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Pretreatment of human LADR mast cells with 100 mM of luteolin showed significant inhibition of histamine, tryptase, matrix metalloproteinase (MMP)-9, vascular endothelial growth factor (VEGF), IL-1B, IL-6, IL-8, and TNF [167]
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It also inhibits TGF-beta1, a cytokine that promotes fibrosis
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