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Local injection site reactions may include: Persistent redness, swelling, or induration at injection sites Itching or burning sensation that extends beyond typical injection discomfort Delayed reactions occurring hours to days after administration Nodule formation or skin changes at injection sites These local reactions differ from common injection site responses, which typically resolve within days and occur as expected medication effects rather than antibody-mediated responses

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1 Cardiovascular and metabolic diseases, including obesity, remain important areas of unmet medical need, and we plan to continue applying our global capabilities to advance a pipeline of investigational treatments that have the potential to fill critical gaps in patient care, including continued development of our oral GIPR antagonist candidate and other earlier obesity programs, Chris Boshoff, MD, PhD, chief scientific officer and president of Research and Development at Pfizer, said in a news release

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