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GLP-1 receptor agonists like Ozempic have transformed weight management and diabetes treatment for millions of patients

Semaglutide (the active ingredient in brand-name drugs Ozempic, Rybelsus, and Wegovy) is a GLP-1 receptor agonist, antidiabetic, and weight loss drug

Chronic MMP-9 production is associated with BBB disruption, independent of the insult, and mediates its pathological effects by decreasing the efficiency of BBB tight junctions (Asahi et al., 2009), and induces the degradation of perineuronal nets (PNNs) that surround fast-spiking parvalbumin positive (FS-PV+) inhibitory interneurons (Figure 2

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