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However, considering cardiovascular benefits, metabolic improvements and low risk of side effects with GLP-1 medications, semaglutide has a favorable risk and benefits ratio, and is considered safer than other medications
Retrieved from Tchang, B
Which genes are controlling blood glucose levels
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Aronne noted the sex-based differences: Women vs men lost a mean of 18% vs 11% on semaglutide and 17.8% vs 11% on tirzepatide
What We Know So Far Body composition research published through 2025 and 2026 has established several findings that are directly relevant to older adults on GLP-1 therapy: Up to 40% of total weight lost on high-efficacy GLP-1 medications is lean body mass rather than fat, according to body composition analyses cited across multiple clinical reviews
