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79 Insulin has also been shown to have anabolic effects on bone by stimulating osteoblasts whilst suppressing osteoclast function
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They noted that these findings aligned with prior pooled evaluations of the Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes (SUSTAIN) and Peptide Innovation for Early Diabetes Treatment (PIONEER) programs, and that eye examinationsimplemented more consistently in later trialshelped strengthen confidence in the findings
A fixed-effect model was used for meta-analysis where heterogeneity was less than 50%
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