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The main limitations of the study are the lack of a control group, the single-center design, and the low sample size, which, although statistically adequate, does not allow for a more in-depth analysis of muscle mass stratified by patient gender

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To evaluate Dihexas ability to cross the BBB and accumulate in brain regions, rats were fitted with carotid cannulas and infused with a mixture of [H]Dihexa (10 Ci) and [C]inulin (2 Ci), a vascular space marker, in 100 l of isotonic saline

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Pitts and Hoffmann, 2017

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