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It is a tripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side chain and the amine group of cysteine, and the carboxyl group of cysteine is attached by normal peptide linkage to a glycine

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In parallel, IMC treatment resulted in marked reductions in the intestinal sterol transporter NiemannPick C1-like 1 (NPC1L1) and reorganization of the gut microbial community, primarily reversing choline-supplemented diet-induced changes

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It is worth mentioning that this kind of interaction might lead to a decrease in intracellular concentration of tamoxifen and thereof lower its ER mediated activities

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