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Tubular structures are defined as those with a length four times their width

Tocilizumab, an IL-6 receptor (IL-6R) antagonist, has been shown to stimulate the bone formation marker P1NP while inhibiting bone resorption markers CTX-1 and ICTP after four weeks of treatment (101)

Eczema fluctuates naturally, so minimum 4 to 8 week assessment periods are needed to distinguish real improvement from disease variation

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