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As the off-label use of these agents continues to grow in type 1 diabetes, particularly in patients with obesity or insulin resistance, our results support the need for continued investigation and consideration of their role as adjunctive therapies, Garg said

Moreover, with the exception of chronic kidney diseases, heterogeneity and pleiotropy were not observed when estimating the effect of GLP1R-based agonists on hepatic and cardiovascular diseases (Table 4)

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doi: 10.1186/s12937-016-0186-5 79 LeeC