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The more recent STEP UP trial tested a higher dose of 7.2 mg and showed average weight loss of 20.7% at 72 weeks
In the withdrawal trial, participants switched to placebo regained about 14% over the following year. Tapering, at least 1.2 g/kg of protein, resistance training, and follow-up reduce the risk, but no post-stop protocol guarantees maintenance
What the Research Shows So Far BPC-157 has been studied for over two decades in animal models and preclinical studies, with consistent findings across a wide range of tissues and systems: BPC-157 has shown an extremely high safety margin in rodents, with no toxicity or organ damage reported even at doses much higher than those typically used in humans. Sikiric, P
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