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doi: 10.18637/jss.v077.b02 53 WalterWSnchez-CaboFRicoteM

Refined formulas may look interesting or enticing, but youre paying more for unfounded claims with benefits that just dont pan out

Vucetic et al., 2011

We think this is a big deal. The company plans to seek regulatory approval for orforglipron for weight management by the end of this year and for the treatment of type 2 diabetes in 2026

In other words, first-pass metabolism describes reduced bioavailability when you consume something orally

Health economists estimate it could add approximately $2.76 billion to overall Wegovy sales by 2030, with its share growing from about 3% in 2026 to 17% by 2031