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Systemic Side Effects Gastrointestinal Side Effects The most commonly reported side effects of GLP-1 RAs are gastrointestinal, including nausea, vomiting, diarrhea, constipation, abdominal pain, and dyspepsia [113,114,115]
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Moreover, the pronounced effect of ketogenic therapy on appetite regulation may further supports its effectiveness as a nutritional strategy for obesity management
Hypoglycemia is a potential adverse effect though this is rare given the glucose-dependent mechanism and is usually seen in patients taking insulin or insulin secretagogues [47]
Hydrophobic ion pairing: altering the solubility properties of biomolecules
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