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La tirzepatida (Mounjaro, Zepbound) es un agonista dual que acta sobre los receptores GIP y GLP-1, no un agonista GLP-1 puro
Semaglutide is also approved for both type 2 diabetes and obesity, with a higher-dose version specifically indicated for obesity treatment
Dysfunction in the mitochondrial Fe-S assembly machinery leads to formation of the chemoresistant truncated VDAC1 isoform without HIF-1alpha activation
The source of this inhibitory input is still to be determined, but recent findings have shown that GABAergic TRH Arc neurons directly suppress the activity of AgRP neurons, respond to GLP-1RA and contribute to its weight loss effects 13
Retatrutide, also known by its development code LY3437943, is a 39-amino-acid synthetic peptide engineered by Eli Lilly
These effects lead to improved glycaemic control and significant weight loss in many patients
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