normally produced by the gut) Examples: Exenatide (Byetta) - Twice/day or weekly injection (ER version) Liraglutide (Saxenda, Victoza) - Daily injection Dulaglutide (Trulicity) - Weekly injection Semaglutide - Weekly injection (Ozempic), or daily tablet (Rybelsus) Major Advantages: Weight loss (~1.5-2.5kg) Liraglutide, dulaglutide, and semaglutide variety of adverse CV outcomes in high risk patients with T2D + atherosclerotic heart disease Contraindications: Personal or family history of medullary thyroid cancer Personal history of pancreatitis Common Side Effects and Toxicities: Gl side effects (e.g
So, while DPP-IVs may offer a better gastrointestinal (GI) adverse event profile than GLP-1RAs, they are generally less effective at reducing HbA 1C and have a lower potential for weight loss
According to the NIH Office of Dietary Supplements, functional B12 deficiency is most commonly seen in patients with one or more of the following: Age over 50 stomach acid production declines with age, and stomach acid is required to free B12 from food PPI or H2 blocker use reflux medications suppress the acid needed for B12 absorption Metformin use, which interferes with B12 absorption directly Vegan or vegetarian diets B12 is found almost exclusively in animal products Gut conditions including celiac, IBS, SIBO, and Crohns MTHFR mutations that affect how B12 is metabolized once absorbed Heavy alcohol use The symptoms of low B12 are easy to dismiss: fatigue, brain fog, low mood, tingling in the hands or feet, weakness, and shortness of breath on mild exertion
Read carefully the potential side effects and cautions of the contents
What are oral GLP-1 drops and how do they work
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