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GSH is synthesized in vivo, by the consecutive action of two ATP-dependent enzymes, from the precursor amino acids cysteine, glutamate and glycine

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The controllable regulation of macrophage immune function through multilevel metabolic reprogramming is likely to become an important direction for the future treatment of autoimmune diseases

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Under oxidative stress, KEAP1 modifications release NRF2, enabling its nuclear translocation to activate antioxidant genes