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Combinations with codeine, tramadol, or other opioid medicines carry additional risks including dependence, sedation, constipation, respiratory depression, and driving impairment

doi: 10.1016/j.cmet.2019.03.009 63 NoureldeinMHBitarSYoussefNAzarSEidAA

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As well as physical health risks, the stigma attached to excess body weight and obesity can have adverse psychosocial consequences and lower the quality of life

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