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An individual participant data meta-analysis of 23 large randomised trials (covering over 150,000 people) found that during the first year of statin therapy, the absolute excess of muscle pain or weakness was about 11 cases per 1,000 people per year

GASTRIC EMPTYING DELAY: Slows gastric emptying, reducing the rate of glucose absorption after meals Attenuates postprandial glucose (PPG) spikes particularly important for T2DM management This effect diminishes with prolonged use (tachyphylaxis), with the pancreatic and hepatic effects remaining dominant 4

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Patience is key when letting the drug naturally reach room temperature

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