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Tambin requieren evaluacin urgente: dolor en el cuadrante superior derecho con fiebre o ictericia (posible problema vesicular), o distensin abdominal marcada con incapacidad para eliminar gases (posible leo u obstruccin intestinal)

Note that the side chain of glutamate and the amide of cysteine are joined through a g-peptide linkage

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With supplemental compounds

For most individuals, this sensation is mild and subsides significantly within the first week or two as the body adapts to the medication