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Researchers believe several mechanisms may contribute to the larger weight reductions observed with retatrutide

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Steele AN, Stapleton LM, Farry JM, Lucian HJ, Paulsen MJ, Eskandari A, et al

PubMed laboratory research record [PMID: 3683188] PubMed record related to this compound for laboratory literature review

The authors also state that surgery should only be a consideration in cases where the melanosis coli occurs alongside a serious malignancy