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Specific proteins reported to be upregulated in CVD (but downregulated with semaglutide treatment, after adjusting for effects of weight loss and HbA 1c reduction) include NPPB (NT-proBNP, released from cardiomyocytes on ventricular distension) 37 , ANGPT2 (involved in vascular remodeling and angiogenesis) 38 , CD93 (involved in cardiovascular homeostasis) 39 , MSR1 (involved in lipid metabolism and immune function) 40,41 , and THBS2 and TNC (both involved in extracellular matrix remodeling) 42
Semaglutide: A glucagon-like peptide-1 (GLP-1) receptor agonist, this medication enhances insulin secretion, reducing glucagon release, and slowing gastric emptying, which helps lower blood sugar levels
doi:10.1093/nutrit/nuw010 4
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Semaglutide details, dosing & cost Compounded Tirzepatide (tirzepatide) Dual-action GIP/GLP-1 compound option offering the same mechanism at a more accessible price point
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