In the STEP trials, participants lost an average of 15-20% of their body weight over 68 weeks, higher than other weight loss medications
The medications are all currently injectables, but if an investigational oral GLP-1 called orforglipron is approved by the U.S
Consider gentle daily psyllium husk with adequate water, 200 to 400 milligrams of magnesium citrate at night to draw water into the stool, or polyethylene glycol 3350 as directed by your physician
Anderson KM, Odell PM, Wilson PW, Kannel WB
In response, enteroendocrine cells upregulate GLP-1 secretion, and GLP-1 receptor activation has been shown to suppress pro-inflammatory cytokines and macrophage infiltration
"The more they wanted, the more frustrated I would get." The 57-year-old power plant worker who lives near Santa Cruz, Calif., had already gotten a Zepbound prescription from his primary care doctor last December to treat the obstructive sleep apnea that was leaving him exhausted every morning