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When nucleoid turnover and endolysosomal disposal are compromised, mtDNA and inner membrane-associated immunostimulatory species accumulate in aberrant location and chronically activate cytosolic DNA sensing and inflammasome pathways, including cGAS-STING and NLRP3 pathway, thereby biasing myeloid and stromal compartments toward type I interferon and IL-1 family responses (144,157,158)

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These changes in gene expression are dependent on the time interval during which the genes were analyzed, as well as the type of vessel investigated

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These tremors are usually mild and tend to decrease as your body adjusts to the medication