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Communications Biology, 8 (1), 1-10

Week-by-Week Timeline: What to Expect Week 1: The Adjustment Phase Most people notice GI effects within hours to a few days of their initial injection or oral dose

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Reduced appetite primarily involves wanting less food

An RCT of 174 patients with severe alcoholic hepatitis found that the combination of prednisolone + NAC (IV for 5 days, then oral for 2 weeks) significantly reduced 1-month mortality compared to prednisolone alone (8% vs 24%, p=0.006), though the difference was not significant at 6 months (Nguyen-Khac et al., N Engl J Med, 2011) [36]