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Everson, C
These drugs include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and tirzepatide (Mounjaro, Zepbound)though tirzepatide is actually a dual GIP/GLP-1 receptor agonist
Developed by Eli Lilly, it is a 39-amino-acid synthetic peptide with a C20 fatty diacid side chain attached via a linker at lysine-20, enabling binding to albumin for once-weekly dosing pharmacokinetics (Jastreboff AM et al., NEJM 2022
Regulatory status varies across medical, retail and athletic contexts
The detection windows are shorter because blood concentrations drop faster than urinary metabolite concentrations for most small-molecule drugs
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