With insulin, there is risk of weight gain, for hypoglycemia, and theres more treatment burden and need for glucose monitoring. GLP-1 drugs have also been shown to have cardiovascular benefits, she adds, though further clinical trials are needed to assess orforgliprons effects on heart health
GLP-1RAs have shown to improve cardiovascular health by decreasing blood pressure, stimulate differentiation of nerve cells and inhibit neuroinflammation, and inhibit hepatitis (7)
Under these conditions, retatrutide shortened the time of muscle relaxation in HAP
The conservative approach: at any dose escalation, implement the step-up protocol proactively (add Miralax the same week you increase dose) rather than waiting for symptoms to become severe
Because of the limit of this study, the potential role of GLP-1R in the TNC still needs to be further explored
This study was published in the International Journal of Colorectal Disease