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Symptoms of severe vitamin B12 deficiency can include visual disturbances, severe joint pain, paresthesia (tingling in the hands and feet), memory problems, depression, anxiety, poor muscle function, ataxia (impaired balance and coordination), changes in reflexes and even infertility

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Copper ions can interact with other peptide sequences, potentially forming unintended coordination complexes that alter both peptides' biological activity

This includes: Reviewing medical history Checking symptoms of deficiency Identifying allergies Evaluating contraindications A good training programme teaches how to conduct patient consultations safely and ethically

Lessons in biology from patients with inborn errors of vitamin B12 metabolism