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Sandoval DA, Bagnol D, Woods SC, DAlessio DA, Seeley RJ

Daugas E, Cand C, Kroemer G

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The lyophilization process removes water to arrest hydrolysis, the primary degradation pathway

Crucially, Crat knockout experiments partially reversed these metabolic improvements, establishing CrAT-mediated SREBP1c inhibition as a key mechanism through which L-carnitine counteracts de novo lipogenesis