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The long answer: Refrigeration is critical because it dramatically slows down two separate but equally problematic processes

When to Reevaluate Your B12 Treatment If you havent felt an energy boost from vitamin B12 injections within the expected timeframe, its time to reevaluate your treatment plan

Science 337 , 10621065 (2012)

Bibcode:1974PNAS...71.3879H

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In response to oxidants, cysteine modification on Keap1 releases NE2FL2, which is then stabilized and transported to the nucleus where it activates transcription of antioxidant genes, including proteasomal PA28