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Glucagonlike peptide1 receptor agonists (GLP1 RAs) have transformed type 2 diabetes management by improving blood sugar control and promoting weight loss

Any weight reduction with metformin is modest and secondary

No inter-study heterogeneity was observed in all of the above analyses

Some patients may respond well to lower-dose approaches, but most long-term clinical evidence is based on standard dosing protocols

Metformin & longevity Healthspan : Strong evidence shows metformin extends years of healthy life by delaying age-related diseases: Reduces cardiovascular disease risk by improving blood vessel health

More than half (59.7%) of patients had type 2 diabetes and 61.7% had obesity