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The cyanobenzyl group at the N1 position of the pyrimidine-2,4-dione compounds is strategically placed in the S 1 domain, and the nitrile group forms a hydrogen bond with Arg125
(2015): Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism
No genotoxicity, mutagenicity, or organ-specific toxicity was reported at the doses tested in the preclinical safety evaluation
That nuance is important
H., Lin, J
This is where the acetylated form, ALCAR, distinguishes itself
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