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Thus, using complementary pharmacological and chemogenetic approaches, we provide evidence that the modulation of GLP-1 signalling in the OB contributes to the maintenance of energy homeostasis, and that augmenting OB GLP-1 signalling can improve metabolic parameters deregulated in the context of obesity
These symptoms develop gradually because the body stores several years worth of B12 in the liver, meaning deficiency takes time to become clinically apparent
Blonde L, Berard L, Saremi A, Huang Y, Aroda VR, Raccah D
Physiol Rev
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