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The Journal of Clinical Endocrinology & Metabolism, 91 (3), 799-805.

Additionally, these drugs may be avoided in the elderly because of an increased risk of confusion [56]

doi: 10.3389/fnut.2022.1007816 77 RojasMRodriguezYAcosta-AmpudiaYMonsalveDMZhuCSLiQZet al

The MTHFD2 enzyme is resistant to inhibition by NADH and so this reaction can contribute to significant mitochondrial NADH production under increased serine catabolism as well as during periods where the major NADH producing catabolic pathways are inhibited by increasing NADH levels

However, under caloric restriction, these changes can paradoxically reduce anabolic signaling, impairing protein synthesis