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The enzyme cystathionine--synthase (CBS) that catalyzes the first step in the transsulfuration pathway is highly expressed in liver cells but not highly expressed in peripheral cells, so it is not surprising that the liver is the major producer of GSH, much of which is exported to the plasma and enzymatically broken down to cysteinylglycine and cyst(e)ine that is subsequently taken up by other cells for GSH synthesis
The influence of methionine, selenomethionine, and vitamin E on liver metabolic pathways and steatosis in high-cholesterol fed rabbits
Known as our body's 'master detoxifier', glutathione is constantly processing and removing toxins through the phase II detoxification pathway
It is not certain whether it is safe to take during pregnancy and breastfeeding
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