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Bradley DP, Kulstad R, Racine N, Shenker Y, Meredith M, Schoeller DA

Some patients report that the oral version, because it is taken daily in smaller doses, may lead to smoother levels of the medication in the body, potentially reducing the intensity of the peaks that can sometimes cause nausea shortly after a weekly injection

Eli Lilly also has a pill version waiting in the wings that promises to be just as effective as semaglutide, precipitating a drop in the Danish companys stock, which has never rebounded to its $615 billion peak in market capitalization nearly two years ago

This outcome reflects both the inherent difficulty of treating Alzheimer's disease and questions about whether a single neuroprotective mechanism, without addressing amyloid and tau pathology more directly, can be sufficient

TB-500 also appears to be generally well-tolerated, but again, safety data derived from adequately powered clinical trials is lacking

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