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Under stress conditions, PINK1 promotes Parkin recruitment to the OMM to ubiquitinate mitochondrial proteins and polyubiquitin chains are subsequently phosphorylated by PINK1 as an initiation signal for autophagy
The authors conclude that the renal benefits cannot solely be explained by weight reduction or risk factor reduction, although these may contribute, and the mechanisms of kidney protection are likely to be multifactorial and may include decreased oxidative stress, inflammation and fibrosis in the kidney
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