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In obese murine models, where 3-AR levels are generally reduced compared to lean mice, AOD 9604 appeared to restore 3-AR expression to levels similar to those seen in lean animals

Related reproductive-biology effects of NNMT inhibition are also under investigation, with some studies noting effects on embryo implantation in models

2000 in Hormone Research showed that 21-day oral AOD-9604 (500 mcg/kg/day) reduced body weight gain by roughly 50% in obese Zucker rats with no insulin sensitivity penalty

Fasted administration is critical because the peptide works by stimulating lipolysis (fat breakdown) through beta-3 adrenergic receptor activation

Well see how B12 shortage affects nerves and the symptoms that follow

Overgrowth of bacteria: Some people develop vitamin B 12 deficiency as a result of conditions that slow the movement of food through the intestines (diabetes, scleroderma, strictures, diverticula), allowing intestinal bacteria to multiply and overgrow in the upper part of the small intestine