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Despite its short duration, the current study had significant results in its composite endpoint, but did not significantly impact the physical activity (6-min walk test), QoL, and mTOR phosphorylation which may have improved with prolonged supplementation
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In summary, current evidence indicates that GLP-1RAs modulate gut microbiota in ways that may underlie their metabolic and organ-protective effects, although heterogeneity between models and trials remains
Type 2 diabetes (T2D) is among the most prevalent chronic metabolic disorders worldwide - driven by insulin resistance, pancreatic dysfunction, obesity, and unhealthy lifestyles
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