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It has no known interaction with semaglutide (which is administered by injection)

These bacteria can produce hydrogen sulfide

Mounjaro/Zepbound (tirzepatide), approved dual GLP-1/GIP agonist for type 2 diabetes and obesity Recent Highlights: In April 2026, the FDA approved orforglipron (Foundayo), making it one of the first oral GLP-1 pills that can be taken any time of day and that has no food or water restrictions

If fatigue is dose-related, lowering your dose doesn't lower your monthly cost, so discuss this option freely with your care team

That said, the quality of what you eat still matters, prioritizing protein and whole foods supports both the medications effects and your overall health

Increased diabetes risk: Multiple meta-analyses have examined whether antidepressant use increases the risk of developing type 2 diabetes