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4 Oxidative stress plays a central initiating role in the pathogenesis of vitiligo: the high metabolic activity of melanocytes leads to excessive generation of reactive oxygen species (ROS), while functional defects in the skins antioxidant system result in ROS accumulation, directly triggering mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis

Nadph oxidases: redox regulation of cell homeostasis and disease

122 (24), e2506321122

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Nagamatsu M, Nickander KK, Schmelzer JD, et al