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229 Specifically, PKA modifies the open state of K-ATP channels through phosphorylation, affecting the cell membranes potential and intracellular calcium ion concentration

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FMT is also being explored: an open-label trial of FMT in MS demonstrated safety and hinted at some improvements in gut microbiome diversity and fatigue scores, and a placebo-controlled Phase I FMT trial in progressive MS is currently underway to assess impacts on MRI lesions and clinical outcomes [203, 204]

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