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Description

Pathogenic variants in the SLC4A1 gene, that are associated with type 1 RTA, are inherited in an autosomal dominant or recessive manner while pathogenic variants in both the ATP6V1B1 and ATP6V0A4 genes are inherited as autosomal recessive traits

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PMID 18832074

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Therefore, therapeutic principles acting via different receptors and postreceptor pathways seem attractive in view of potentially additive or synergistic effects

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