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[See Warnings and Precautions and Adverse Reactions.] Warnings and Precautions Use in Patients with Renal Insufficiency A dosage adjustment is recommended in patients with moderate or severe renal insufficiency and in patients with ESRD requiring hemodialysis or peritoneal dialysis

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Maalouf M, Rho JM, Mattson MP (2009) The neuroprotective properties of calorie restriction