Although more research is needed to solidify these findings, evidence published by the American Academy of Pain Medicine points to the efficacy of B12 as an adjunctive treatment alongside lidocaine for pain management
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It has also been shown to be the causative factor in many cases of pediatric neuropathy (Dobrozsi, Flood, Panepinto, Scott & Brandow, 2013)
Due to the complicating factor of a shot and the extra cost, it seems the best route for most people is to focus on getting adequate B vitamins from food, and supplement as necessary.
Once opened, exposure to air/oxygen increases oxidation risk, and using sterile technique (especially for reconstituted solution) is essential