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Figure 1 Additionally, other endocrine parts of the body (including the adrenal glands, thyroid gland, pancreas, and fat tissue) communicate with the HPG axis and accessory organs to achieve adequate production of sex hormones and sperm quality and quantity

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Systemic and endothelial inflammation contribute to collagen deposition, interstitial fibrosis and therefore atrial and ventricular remodelling as well as vascular stiffening [9, 10]

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2.3 Patient 3 A 25-year-old male with PWS, resulting from a uniparental maternal disomy was seen at our Endocrinology Unit