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Most of the biologically active T 3 in the circulation and inside cells is generated by the removal of one iodine atom from T 4 in a reaction catalyzed by selenium-dependent iodothyronine deiodinase enzymes

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CJC-1295 (No DAC) a tetra-substituted analog of GHRH binds to GHRH receptors on pituitary somatotroph cells, stimulating GH release via cAMP and IP-mediated signaling