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14 about 22 and 12 discordant monozygotic twin pairs, demonstrated that endurance exercise did not affect degeneration of the IVDs, while weightlifting had mild effects only on the thoracic, but not the lumbar spine

Not every patient achieves the weight loss targets they are hoping for, and a meaningful proportion of patients even on maximum doses do not reach the 1520% body weight reduction that clinical guidelines increasingly use as a benchmark for meaningful metabolic benefit

There is evidence here

10.1155/2022/1792894 241 LeeK

& Nicholls, D

While generally safe and well-tolerated, individuals with copper metabolism disorders, such as Wilsons disease, should avoid this treatment