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Anal fissures can also occur in patients who have other GI symptoms or medical conditions such as Crohn disease (an inflammatory disease of the intestines)

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The surface protein called SpaCBA in LGG affects the levels of TNF-, IL-10, IL-6, and IL-12 through a TLR2-dependent mechanism, stimulating immune responses 124

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Nausea, in particular, can create a sense of unease or worry about vomiting, especially in social situations

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