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Some have argued that obesity is a severely under-treated condition, despite its high prevalence, comorbidity with many physical and mental health disorders, and associated mortality and societal cost 246
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Prader-Willi syndrome Prader-Willi syndrome is a genetic disorder characterized by a constant sense of hunger, leading to hyperphagia and often to comorbid obesity (van Nieuwpoort et al., 2021)
The Bulletproof diet suggests an extended daily fast (14-18 hours), which is achieved by consuming only coffee enriched with grass-fed butter and coconut oil in the morning and consuming a healthy low-carbohydrate meal in the evening
Additionally, tirzepatide was designed to bind to the GIPR with an affinity 5-fold stronger than that for the GLP1R, resulting in greater potency and selectivity in engaging the GIPR over the GLP1R
However, its still important to be aware of potential interactions
