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[8] Although not an absolute contraindication, patients with coronary artery disease or unstable angina should only use B-Complex injections containing niacinamide under physician supervision, since high-dose niacin supplements have been linked to arrhythmias in such patients

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Quick answer In the research literature the 5 mg AOD-9604 vial is typically reconstituted with 3 mL of bacteriostatic water, and documented research protocols reference 300 mcg per dose drawn from the resulting solution