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Isosinensetin stimulates glucagon-like peptide-1 secretion via activation of hTAS2R50 and the G()-mediated signaling pathway

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Eukaryotic PI-PLCs are large (80150 kDa) and consist of several distinct domains that play predominant roles in signal transduction and generate inositol 1,4,5-triphosphate (IP3) and DAG by the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2)